If there are large changes in the rate of removal of a drug, then this can lead in extremis to severe problems in the outcome of the patient’s treatment: the first is drug failure, whilst the second is drug toxicity (Figure 1.2). These extremes and indeed all drug effects are directly related to the blood […]
Definitions The consequences for the patient when drug concentrations either fall below the therapeutic window or exceed it can be life threatening. The rate of removal of the drug from the body determines whether it will disappear from, or accumulate in the patient’s blood. A concept has been devised to understand and measure rate of […]