1. Introduction Detection of statistical signals in protein and DNA sequences is often a powerful method for uncovering biological significance and function. Examples of sequence features that can be identified through their statistical properties include protein motifs (see Article 28, Computational motif discovery, Volume 7), gene promoters, enhancers and suppressors (see Article 19, Promoter prediction, […]
1. Introduction The major source of all the challenges is the limitation in sequencing technologies, which today allows us to routinely sequence only about 500 to 800 bases of contiguous DNA sequence. To overcome the limitation of short contiguous sequences, Frederick Sanger devised the shotgun sequencing technique and in 1982 demonstrated its potential by sequencing […]