Divergence of WEE Virus
B. Divergence of Enterovirus 70
10-3 subs/nt/year
Slope = 5.0
10-4 subs/nt/year
Slope = 2.8
Years after initial isolation
Year of isolation
C. Divergence of Influenza HA (H3 subtype)
Third Codon Position
Slope = 1.0  10-2 subs/nt/yr
First and Second
Codon Positions
Slope = 5.0  10-3 subs/nt/yr
Year of isolation
FIGURE 3.44  Divergence plots for two different plus-strand RNA viruses, which differ by more than an order of
magnitude in their divergence rates, and a minus-strand virus. Data for (A) are from Weaver et al. (1997) for 477
nucleotides of the C terminus of the E1 protein-coding region, for (B) from Takeda et al. (1994) for the 918 nucleotides
which encode the VP1 protein, and for (C) from Saitou and Nei (1986) for the 1700 nt encoding the hemagglutinin. In
(B) the dots are color coded by location of isolation: red, North Africa; orange, Europe; yellow, Pakistan; green, South
East Asia; blue, Japan; purple, Honduras.
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