Laboratory Values of Clinical Importance (Rheumatology) Part 6

TABLE A-9

STOOL ANALYSIS

REFERENCE RANGE

SI UNITS

CONVENTIONAL UNITS

Amount

0.1-0.2 kg/d

100-200 g/24 h

Coproporphyrin

611-1832 nmol/d

400-1200 μg/24 h

Fat

Adult

<7 g/d

Adult on fat-free diet

<4 g/d

Fatty acids

0-21 mmol/d

0-6 g/24 h

Leukocytes

None

None

Nitrogen

<178 mmol/d

<2.5 g/24 h

pH

7.0-7.5

Occult blood

Negative

Negative

Trypsin

20-95 U/g

Urobilinogen

85-510 μmol/d

50-300 mg/24 h

Uroporphyrins

12-48 nmol/d

10-40 μg/24 h

Water


<0.75

<75%

TABLE A-10

RENAL FUNCTION TESTS

REFERENCE RANGE

SI UNITS

CONVENTIONAL UNITS

Clearances (corrected to 1.72 m2 body surface area)

Measures of glomerular filtration rate

Inulin clearance (Cl)

Males (mean ± 1 SD)

2.1 ± 0.4 mL/s

124 ± 25.8 mL/min

Females (mean ± 1 SD)

2.0 ± 0.2 mL/s

119 ± 12.8 mL/min

Endogenous creatinine clearance

1.5-2.2 mL/s

91-130 mL/min

Measures of effective renal plasma flow and tubular function p-Aminohippuric acid clearance (ClPAH)

Males (mean ± 1 SD)

10.9 ±2.7 mL/s

654 ± 163 mL/min

Females (mean ± 1 SD)

9.9 ± 1.7 mL/s

594 ± 102 mL/min

Concentration and dilution test

Specific gravity of urine

After 12-h fluid restriction

>1.025

>1.025

After 12-h deliberate water intake

<1.003

<1.003

Protein excretion, urine

<0.15 g/d

<150 mg/d

Specific gravity, maximal range

1.002-1.028

1.002-1.028

Tubular reabsorption, phosphorus

0.79-0.94 of filtered load

79-94% of filtered load

TABLE A-11

CIRCULATORY FUNCTION TESTS

RESULTS: REFERENCE RANGE

TEST

SI UNITS (RANGE)

CONVENTIONAL UNITS (RANGE)

Arteriovenous oxygen difference

30-50 mL/L

30-50 mL/L

Cardiac output (Fick)

2.5-3.6 L/m2 of body surface area per min

2.5-3.6 L/m2 of body surface area per min

Contractility indexes

Max. left ventricular dp/dt (dp/dt)/DP when DP = 5.3 kPa

220 kPa/s (176-250 kPa/s) (37.6 ± 12.2)/s

1650 mmHg/s (1320-1880 mmHg/s) (37.6 ± 12.2)/s

(40 mmHg) (DP, diastolic pressure)

Mean normalized systolic ejection rate (angiography)

3.32 ± 0.84 end-diastolic volumes per second

3.32 ± 0.84 end-diastolic volumes per second

Mean velocity of circumferential fiber shortening (angiography)

1.83 ± 0.56 circumferences per second

1.83 ± 0.56 circumferences per second

Ejection fraction: stroke volume/ end-diastolic volume (SV/EDV)

0.67 ± 0.08 (0.55-0.78)

0.67 ± 0.08 (0.55-0.78)

End-diastolic volume

70 ± 20.0 mL/m2 (60-88 mL/m2)

70 ± 20.0 mL/m2 (60-88 mL/m2)

End-systolic volume

25 ± 5.0 mL/m2 (20-33 mL/m2)

25 ± 5.0 mL/m2 (20-33 mL/m2)

Left ventricular work

Stroke work index

50 ± 20.0 (g-m)/m2 (30-110)

50 ±20.0 (g-m)/m2 (30-110)

Left ventricular minute work index

1.8-6.6 [(kg-m)/m2]/min

1.8-6.6 [(kg-m)/m2]/min

Oxygen consumption index

110-150 mL

110-150 mL

Maximum oxygen uptake

35 mL/min (20-60 mL/min)

35 mL/min (20-60 mL/min)

Pulmonary vascular resistance

2-12 (kPa-s)/L

20-130 (dyn-s)/cm5

Systemic vascular resistance

77-150 (kPa-s)/L

770-1600 (dyn-s)/cm5

TABLE A-12

GASTROINTESTINAL TESTS

TEST

RESULTS

SI UNITS

CONVENTIONAL UNITS

Absorption tests

D-Xylose: after overnight fast, 25 g xylose given in oral aqueous solution

Urine, collected for following 5 h

25% of ingested dose

25% of ingested dose

Serum, 2 h after dose

2.0-3.5 mmol/L

30-52 mg/dL

Vitamin A: a fasting blood specimen is obtained

Serum level should rise to

Serum level should rise to twice

and 200,000 units of vitamin A in oil is given orally

twice fasting level in 3-5 h

fasting level in 3-5 h

Bentiromide test (pancreatic function): 500 mg bentiromide (chymex) orally; p-aminobenzoic acid (PABA) measured

Plasma

>3.6 (±1.1) μg/mL at 90 min

Urine

>50% recovered in 6 h

>50% recovered in 6 h

Gastric juice

Volume

24 h

2-3 L

2-3 L

Nocturnal

600-700 mL

600-700 mL

Basal, fasting

30-70 mL/h

30-70 mL/h

Reaction

pH

1.6-1.8

1.6-1.8

Titratable acidity of fasting juice

4-9 μmol/s

15-35 meq/h

Acid output

Basal

Females (mean ± 1 SD)

0.6 ± 0.5 μmol/s

2.0 ± 1.8 meq/h

Males (mean ± 1 SD)

0.8 ± 0.6 μmol/s

3.0 ± 2.0 meq/h

Maximal (after SC histamine acid phosphate, 0.004 mg/kg body weight, and preceded by 50 mg promethazine, or after betazole, 1.7 mg/kg body weight, or pentagastrin,

6 μg/kg body weight)

Females (mean ± 1 SD)

4.4 ± 1.4 μmol/s

16 ± 5 meq/h

Males (mean ± 1 SD)

6.4 ± 1.4 μmol/s

23 ± 5 meq/h

Basal acid output/maximal acid output ratio

<0.6

<0.6

Gastrin, serum

0-200 μg/L

0-200 pg/mL

Secretin test (pancreatic exocrine function): 1 unit/kg body weight, IV

Volume (pancreatic juice) in 80 min

>2.0 mL/kg

>2.0 mL/kg

Bicarbonate concentration

>80 mmol/L

>80 meq/L

Bicarbonate output in 30 min

>10 mmol

>10 meq

TABLE A-13

NORMAL VALUES OF DOPPLER ECHOCARDIOGRAPHIC MEASUREMENTS IN ADULTS

RANGE

MEAN

RVD (cm), measured at the base in apical 4-chamber view

2.6-4.3

3.5 ± 0.4

LVID (cm), measured in the parasternal long axis view

3.6-5.4

4.7 ± 0.4

Posterior LV wall thickness (cm)

0.6-1.1

0.9 ± 0.4

IVS wall thickness (cm)

0.6-1.1

0.9 ± 0.4

Left atrial dimension (cm), antero-posterior dimension

2.3-3.8

3.0 ± 0.3

Aortic root dimension (cm)

2.0-3.5

2.4 ± 0.4

Aortic cusps separation (cm)

1.5-2.6

1.9 ± 0.4

Percentage of fractional shortening

34-44%

36%

Mitral flow (m/s)

0.6-1.3

0.9

Tricuspid flow (m/s)

0.3-0.7

0.5

Pulmonary artery (m/s)

0.6-0.9

0.75

Aorta (m/s)

1.0-1.7

1.35

Note: RVD, right ventricular dimension; LVID, left ventricular internal dimension; LV, left ventricle; IVS, interventricular septum.

TABLE A-14

SUMMARY OF VALUES USEFUL IN PULMONARY PHYSIOLOGY

TYPICAL VALUES

SYMBOL

MAN, AGE 40, 75 kg, 175-cm TALL

WOMAN, AGE 40, 60 kg, 160-cm TALL

Pulmonary Mechanics

Spirometry—volume-time curves

Forced vital capacity

FVC

5.1 L

3.6 L

Forced expiratory volume in 1 s

FEV1

4.1 L

2.9 L

FEV/FVC

FEV1lXo

80%

82%

Maximal mid-expiratory flow

MMF (FEF 25-27)

4.8 L/s

3.6 L/s

Maximal expiratory flow rate

MEFR (FEF 200-1200)

9.4 L/s

6.1 L/s

Spirometry—flow-volume curves

Maximal expiratory flow at 50% of expired vital capacity

Vmax 50 (FEF 50%)

6.1 L/s

4.6 L/s

Maximal expiratory flow at 75% of expired vital capacity

Vmax 75 (FEF 75%)

3.1 L/s

2.5 L/s

Resistance to airflow

Pulmonary resistance

RL (RL)

<3.0 (cmH2O/s)/L

Airway resistance

Raw

<2.5 (cmH2O/s)/L

Specific conductance

SGaw

>0.13 cmH2O/s

Pulmonary compliance

Static recoil pressure at total lung capacity

Pst TLC

25 ± 5 cmH2O

Compliance of lungs (static)

CL

0.2 L cmH2O

Compliance of lungs and thorax

C(L + T)

0.1 L cmH2O

Dynamic compliance of 20 breaths per minute

C dyn 20

0.25 ± 0.05 L/cmH2O

Maximal static respiratory pressures

Maximal inspiratory pressure

MIP

>90 cmH2O

>50 cmH2O

Maximal expiratory pressure

MEP

>150 cmH2O

>120 cmH2O

Lung Volumes

Total lung capacity

TLC

6.7 L

4.9 L

Functional residual capacity

FRC

3.7 L

2.8 L

Residual volume

RV

2.0 L

1.6 L

Inspiratory capacity

IC

3.3 L

2.3 L

Expiratory reserve volume

ERV

1.7 L

1.1 L

Vital capacity

VC

5.0 L

3.4 L

Gas Exchange (Sea Level)

Arterial O2 tension

Pao2

12.7 ± 0.7 kPa (95 ± 5 mmHg)

Arterial CO2 tension

PaCO2

5.3 ± 0.3 kPa (40 ± 2 mmHg)

Arterial O2 saturation

Sao2 pH 2

0.97 ± 0.02 (97 ± 2%)

Arterial blood pH

7.40 ± 0.02

Arterial bicarbonate

HCO3-

24 + 2 meq/L

Base excess

BE

0 ± 2 meq/L

Diffusing capacity for carbon monoxide (single breath)

DLCO

0.42 mL CO/s per mmHg (25 mL CO/min per mmHg)

Dead space volume

VD

2 mL/kg body wt

Physiologic dead space; dead space-tidal volume ratio

Vo/VT

Rest

<35% VT

Exercise

<20% VT

Alveolar-arterial difference for O2

P(A – a)o2

<2.7 kPa <20 kPa (<20 mmHg)

Miscellaneous

TABLE A-15

BODY FLUIDS AND OTHER MASS DATA

SI UNITS

REFERENCE RANGE

CONVENTIONAL UNITS

Ascitic fluid

Body fluid

Total volume (lean) of body weight

50% (in obese) to 70%

Intracellular

0.3-0.4 of body weight

Extracellular

0.2-0.3 of body weight

Blood

Total volume

Males

69 mL per kg body weight

Females

65 mL per kg body weight

Plasma volume

Males

39 mL per kg body weight

Females Red blood cell volume

40 mL per kg body weight

Males

30 mL per kg body weight

1.15-1.21 L/m2 of body surface area

Females

25 mL per kg body weight

0.95-1.00 L/m2 of body surface area

Body mass index

18.5-24.9 kg/m2

18.5-24.9 kg/m2

TABLE A-16

RADIATION-DERIVED UNITS

QUANTITY

OLD UNIT

SI UNIT

NAME FOR SI UNIT (AND ABBREVIATION)

CONVERSION

Activity

curie (Ci)

Disintegrations per second (dps)

becquerel (Bq)

1 Ci = 3.7 X 1010 Bq 1 mCi = 37 mBq 1 μΦ = 0.037 MBq or 37 GBq 1 Bq = 2.703 X 10-11 Ci

Absorbed dose

rad

joule per kilogram (J/kg)

gray (Gy)

1 Gy = 100 rad 1 rad = 0.01 Gy 1 mrad = 10-3 cGy

Exposure

roentgen (R)

coulomb per kilogram (C/kg)

1 C/kg = 3876 R 1 R = 2.58 X 10-4 C/kg 1 mR = 258 pC/kg

Dose equivalent

rem

joule per kilogram (J/kg)

sievert (Sv)

1 Sv = 100 rem 1 rem = 0.01 Sv 1 mrem = 10 μSv

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