An intense, involuntary contraction of a muscle or muscle group that can be quite painful. Muscle spasms can occur without apparent reason or be a consequence of overuse or excessive time spent in one position. The dystonia that develops in later stages of Parkinson’s is a severe spasm in which the muscles remain held in a contracted state for an extended time, causing pain and awkward positioning. Adjusting the Levodopa dosage sometimes lessens the occurrence of dystonia. restless leg syndrome (RLS), in which the legs twitch and tingle, often includes muscle spasms. sometimes massaging the area helps the muscles to relax. muscle relaxant medications often are necessary to interrupt the nerve signals causing the contractions when dystonia and spasms become frequent or disruptive.