Lipoprotein/Cholesterol Metabolism

SREBP cleavage activating protein (SCAP) A cholesterol-sensing protein that, in the absence of cholesterol, escorts SREBP from the endoplasmic reticulum to the Golgi, where it is proteolytically activated. Statins Cholesterol-lowering drugs that act by inhibiting cholesterol synthesis and upregulating the LDL receptor.

Sterol responsive element binding protein (SREBP) A transcription factor that postively regulates sterol-responsive genes, is attached to the endoplasmic retic-ulum membrane, and is released through a cholesterol-sensitive proteolysis step. Tangier disease A severe HDL deficiency syndrome caused by homozygous mutations at the ABCA1 locus. VLDL Very low density lipoprotein; a triglyceride-rich lipoprotein assembled in the endoplasmic reticulum and Golgi of hepatocytes and then secreted into the bloodstream. While in the circulation, it gives rise to IDL and then LDL after it loses triglyceride.

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