Introduction Prion diseases are fatal neurodegenerative disorders of humans and animals, which result from the conformational conversion of a normal, cell surface glycoprotein (PrPC) into a pathogenic isoform (PrPSc) that is the main component of infectious prions (1,2). Familial prion diseases, which include 10% of the cases of Creutzfeldt-Jakob disease and all cases of Gerstmann-Straussler […]