1. Genome compartmentalization Thirty years ago, we discovered that the bovine genome (neglecting satellite DNAs, which consist of tandemly repeated short sequences) was made of DNA molecules (about 30 kb in size in our work) of fairly uniform GC levels (GC is the molar percentage of guanine+cytosine in DNA). These DNA molecules belonged to a […]
Pseudogenes are genomic regions that derive from genes but have no function (Balakirev and Ayala, 2003; Mighell et al., 2000; Vanin, 1985; Zhang and Gerstein, 2004). Because they have been traditionally assumed to present no biological relevance, the identification and classification of pseudogenes has attracted little attention and was initially restricted to evolutionary studies. Over […]