Chemistry Reference
In-Depth Information
Fig. 6.15 a
The structure of Tp-Azo COF.
b
Tp-Azo COF showing the hexagonal one-
dimensional channels.
c
Graphical representation of proton conduction along the 1D channels.
Reprinted by permission from Macmillan Publishers Ltd.: Ref. [
25
], copyright 2014
6.6 Antibacterial Performance
In 2013, our group first reported quaternary pyridinium-type PAFs, denoted as
PAF-50 (Fig.
6.16
) [
26
]. It was prepared via condensation of 4-pyridinylboronic
acid and cyanuric chloride. The targeted PAFs possessed the cationic centers of
quaternary pyridinium ions. The unprecedented antimicrobials PAF-1 is known to
be nontoxic to mammalian cells and antibacterial. Because the pores of PAF-50
contain Cl
−
as counter-ions and their sizes (5 Å) are sufficiently large to accom-
modate Ag
+
ions with kinetic diameter of 2.52 Å, we were encouraged to produce
AgCl-loaded PAF-50. After loading AgCl inside their micropores (Fig.
6.16
d),
AgCl-PAF-50 integrates the excellent antimicrobial properties of quaternary
ammonium and AgCl (Fig.
6.17
). Besides, the aromatic framework exhibits the
excellent compatibility with various organic solvents and conventional polymers.
The complex of AgCl-PAF-50 and polymer leads to great operation ease and
flexibility for large-scale antibacterial coating on the surfaces of diverse medical
devices simply via solution coating or spray.
