Biomedical Engineering Reference
In-Depth Information
b
c
10
2
80
a
10
1
60
100
10
0
40
50
10
-1
20
0
500
10
-2
0
0
100
200
300
400
0.0
0.1
0.2
0.3
0.0
0.2
0.4
0.6
0.8
1.0
Time (ms)
I
b
/I
o
t
off
(ms)
e
f
g
10
4
d
120
Long duration
events
Short duration
events
Long Events
Short Events
2000
10
3
100
10
2
1500
100
80
10
1
60
1000
50
10
0
40
500
10
-1
20
0
10
-2
0
0
0
100
200
300
400
500
0.0
0.1
0.2
0.3
0.0
0.2
0.4
0.6
0.8
1.0
0 0 0 0 0 0
I
b
/I
o
t
off
(ms)
t
off
(ms)
Time ( ms)
Fig. 13.10
Upper panel
: translocation of (dA)
20
in the mutant (M113F)
7
a
HL pore in 1 MNaCl solution. (a) Representative single channel current
recording trace; (b) scatter plot of event amplitude vs. residence time; and (c) event residence time histogram.
Lower panel
: Translocation of (dA)
20
in the mutant (M113F)
7
a
HL pore in 1 M BMIM-Cl solution. (d) Representative single channel current recording trace; (e) scatter plot of event
amplitude vs. residence time; (f) residence time histogram of short-lived events; and (g) residence time histogram of long duration events. I
b
/I
o
in
(b) and (e) is normalized blockage residual current, which was obtained by dividing the average blockage residual current of an event by the
average open channel current. Figure reprinted with permission from [
70
]. Copyright 2009 American Chemical Society
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