Biomedical Engineering Reference
In-Depth Information
Chapter 8
Solid-State Nanopores: Methods
of Fabrication and Integration,
and Feasibility Issues in DNA Sequencing
Xinsheng Sean Ling
Abstract In this chapter, we review several strategies for the fabrication of
solid-state nanopores in the context of the ultimate goal of a DNA sequencing
and biomolecular analysis technology using these devices. The feasibility of a
proposed DNA sequencing platform using solid-state nanopores and hybridization
probes is discussed.
Keywords Nanopore DNA sequencing Solid-state nanopores TEM-drilling
DNA hybridization Hybridization-assisted sequencing HANS Mean
first-passage time Fokker-Planck equation 1D driven diffusion
8.1
Introduction
In his renowned lectures given in the 1960s, theoretical physicist Richard Feynman
once famously declared that “everything that living things do can be understood in
terms of jiggling and wiggling of atoms.” Nearly half century later, many solid-state
physicists are venturing into the realm of biological systems with the goal of
developing solid-state techniques to probe the “jiggling and wiggling” atoms and
to uncover new insights into molecular biology. The emergence of nanobioscience
in recent years is a natural evolution for solid-state physicists for whom making
small devices is a way of life. In the push for smaller and faster electronic devices,
many micro and nanofabrication techniques have become widely accessible. It is
now possible to make devices that are of the length scales of biomolecules.
Solid-state nanopores are one of these latest examples.
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