Biology Reference
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Figure 19.2 a5 Integrin resides in vesicles. In a5-GFP expressing WI38 cells, integrin
vesicles emanated from the leading edge of a protrusion and moved toward a perinuclear
region (small arrows). The large number of vesicular structures around the perinuclear
region makes tracking individual vesicles dicult. Also note that in the migrating
fibroblast, a5-GFP is detected in tracks behind the cell (large arrows). However, neither
paxillin nor a-actinin is detected in these tracks indicating that the cleavage of the integrin-
cytoskeletal linkage occurs at or very close to the integrin. Scale bar
ΒΌ
20 mm
