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In-Depth Information
Conclusions
WASp and WAVE family proteins act downstream of Cdc42 and Rac to
induce formation of filopodia and lamellipodia, respectively. These structures
are necessary for generating movement force at the leading edge of the cell.
However, WASp and WAVE family proteins may not be critically involved in
random migration of cells. Formation of invasive projections such as
podosomes, and invasion into a collagen gel appear to be N-WASp-dependent
processes. These data indicate that N-WASp assembles actin filaments and
consequently concentrates MMPs at the tips of cellular projections for
movement. WAVEs then assemble actin filaments to a mesh-like structure
that generates moving force to invade through the ECM.
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