Chemistry Reference
In-Depth Information
reproducible and sensitive in Android and iOS platforms. The technology has utility
in resource-limited settings, where trained healthcare professionals are scarce.
While this chapter demonstrated an equipment-free smartphone reader under
controlled conditions, advanced apps need to be developed to automatically com-
pensate for measurement variability due to changes in focus, angle, lighting con-
ditions, shadow effects and sensor type. Additionally, a step forward in this process
is the design of algorithms that process data ef
ciently into actionable information
for the user. The colour conversion method demonstrated in this chapter is not
limited to urinalysis, but is also applicable to other colorimetric assays such as
colloidal gold, latex labels, aqueous tests, as well as emerging technologies such as
holographic sensors [ 26
32 ], optical devices [ 33
35 ], plastic/PDMS-based micro-
-
-
fl
fluidic
devices [ 43 , 44 ]. Furthermore, cloud computing can be adapted for transferring the
medically-relevant data to a centralised facility, and it may be used for endemic or
pandemic surveillance. The app will facilitate less expensive laboratory testing in
the developed nations and enable automated readouts of point-of-care diagnostics in
resource-limited settings. However, successful commercialisation of mobile medi-
cal applications will require clinical trials and FDA clearance to ensure patient
safety [ 45 ].
fluidic devices [ 36
42 ], multiplex paper- and nitrocellulose-based micro
fl
-
References
1. Urdea M, Penny LA, Olmsted SS, Giovanni MY, Kaspar P, Shepherd A, Wilson P, Dahl CA,
Buchsbaum S, Moeller G, Hay Burgess DC (2006) Requirements for high impact diagnostics
in the developing world. Nature 444(Suppl 1):73
79. doi: 10.1038/nature05448
2. Whitesides GM (2013) A glimpse into the future of diagnostics. Clin Chem 59(4):589
-
591.
-
doi: 10.1373/clinchem.2013.204347
3. Girosi F, Olmsted SS, Keeler E, Hay Burgess DC, Lim YW, Aledort JE, Rafael ME, Ricci
KA, Boer R, Hilborne L, Derose KP, Shea MV, Beighley CM, Dahl CA, Wasserman J (2006)
Developing and interpreting models to improve diagnostics in developing countries. Nature
444(Suppl 1):3 - 8. doi: 10.1038/nature05441
4. Gordon J, Michel G (2012) Discerning trends in multiplex immunoassay technology with
potential for resource-limited settings. Clin Chem 58(4):690 - 698. doi: 10.1373/clinchem.2011.
176503
5. Yager P, Domingo GJ, Gerdes J (2008) Point-of-care diagnostics for global health. Annu Rev
Biomed Eng 10:107
144. doi: 10.1146/annurev.bioeng.10.061807.160524
6. Gubala V, Harris LF, Ricco AJ, Tan MX, Williams DE (2012) Point of care diagnostics: status
and future. Anal Chem 84(2):487
-
515. doi: 10.1021/ac2030199
7. Webster M, Kumar V (2012) Automated doctors: cell phones as diagnostic tools. Clin Chem
58(11):1607
-
1609. doi: 10.1373/clinchem.2012.194555
8. Mobile-Cellular Subscriptions (2014) International Telecommunication Union, Place des
Nations. http://www.itu.int . Accessed 27 Oct 2014
9. Lee DS, Jeon BG, Ihm C, Park JK, Jung MY (2011) A simple and smart telemedicine device
for developing regions: a pocket-sized colorimetric reader. Lab Chip 11(1):120
-
126. doi: 10.
-
1039/c0lc00209g
Search WWH ::




Custom Search