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that cooperative effects can play in hydrogen-bonding networks, it is impera-
tive that methods be able to describe the nonadditivity as well as the 2-body
interactions. A consistent benchmark cluster database for the entire range of
noncovalent interactions will play an essential role in the development of prac-
tical computational strategies for large clusters and explicit solvation models.
ACKNOWLEDGMENTS
I thank the current and former members of my research group at the University of
Mississippi for their assistance and input during the preparation of this review, and I would
also acknowledge the National Science Foundation for financial support
(CHE-0517067,
EPS-0132618).
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