Biomedical Engineering Reference
In-Depth Information
studies of the mechanisms of exacerbations have identified a number of
therapeutic targets. Reduction of COPD exacerbation will have an impor-
tant impact on the considerable morbidity and mortality associated with
COPD.
REFERENCES
1. Seemungal TAR, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha
JA. Effect of exacerbation on quality of life in patients with chronic obstructive
pulmonary disease. Am J Respir Crit Care Med 1998; 151:1418-1422.
2. Donaldson GC, Seemungal TAR, Bhowmik A, Wedzicha JA. The relationship
between exacerbation frequency and lung function decline in chronic obstruc-
tive pulmonary disease. Thorax 2002; 57:847-852.
3. Bhowmik A, Seemungal TAR, Sapsford RJ, Wedzicha JA. Relation of sputum
inflammatory markers to symptoms and physiological changes at COPD
exacerbations. Thorax 2000; 55:114-200.
4. Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic
bronchitis during exacerbations. Am J Respir Crit Care Med 1994; 150:
1646-1652.
5. Qiu Y, Zhu J, Bandi V, et al. Biopsy neutrophilia, neutrophil chemokin and
receptor gene expression in severe exacerbations of chronic obstructive pulmon-
ary disease. Am J Respir Crit Care Med 2003; 168:968-975.
6. Bhowmik A, Seemungal TAR, Sapsford RJ, Devalia JL, Wedzicha JA. Com-
parison of spontaneous and induced sputum for investigation of airway inflam-
mation in chronic obstructive pulmonary disease. Thorax 1998; 53:953-956.
7. Seemungal TAR, Harper-Owen R, Bhowmik A, Jeffries DJ, Wedzicha JA.
Detection of rhinovirus in induced sputum at exacerbation of chronic obstruc-
tive pulmonary disease. Eur Resp J 2000; 16:677-683.
8. Seemungal TAR, Harper-Owen R, Bhowmik A, et al. Respiratory viruses,
symptoms and inflammatory markers in acute exacerbations and stable chronic
obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164:
1618-1623.
9. Subauste MC, Jacoby DB, Richards SM, Proud D. Infection of a human
respiratory epithelial cell line with rhinovirus. J Clin Invest 1995; 96:549-557.
10. Roland MA, Bhowmik A, Sapsford RJ, Seemungal TAR, Jeffries DJ, Warner
T, Wedzicha JA. Sputum and plasma endothelin-1 in exacerbations of chronic
obstructive pulmonary disease. Thorax 2001; 56:30-35.
11. Hill AT, Bayley DL, Campbell EJ, Hill SL, Stockley RA. Airways inflamma-
tion in chronic bronchitis: the effects of smoking and alphal-antitrypsin defi-
ciency. Eur Resp J 2000; 15:886-890.
12. Caramori G, Romagnoli M, Casolari P, et al. Nuclear localisation of p65 in
sputum macrophages but not in sputum neutrophils during COPD exacerba-
tions. Thorax 2003; 58:348-351.
13. Dekhuijzen PNR, Aben KKH, Dekker I, et al. Increased exhalation of hydro-
gen peroxide in patients with stable and unstable chronic obstructive pulmon-
ary disease. Am J Respir Crit Care Med 1996; 154:813-816.
Search WWH ::




Custom Search