Biomedical Engineering Reference
In-Depth Information
Figure 3
The CXC chemokine receptors on neutrophils. The IL-8 binds with low
affinity to CXCR1, resulting in adhesion and activation and to CXCR2 with high
affinity resulting in chemotaxis. The CXCR2 is also activated by other CXC chemo-
kines, including growth-related oncogene (GRO)-
a
,-
b
and -
g
, epithelial cell-derived
neutrophil-activating peptide of 78 kD (ENA-78) and granulocyte chemotactic
protein (GCP)-2.
Figure 4
Activation of the CXC chemokines IL-8 and growth-related oncogene
(GRO)-
a
via NF-
k
B after stimulating with TNF-
a
, bacteria and viruses. This results
in chemotaxis of neutrophils and monocytes that differentiate into alveolar
macrophages.
