Biomedical Engineering Reference
In-Depth Information
VI.
SUMMARY
The studies reviewed above are consistent with the concept that the lung is
a dynamic organ where tissue repair and turnover are required for the
maintenance of normal structure. If repair processes are inadequate or
disregulated, then remodeling and dysfunction occur. Epithelial cells could
be considered the central players in many proposed pathogenic mechanisms
for repair and remodeling in COPD. Restoration of a normal epithelium
may be essential to the resolution of airway inflammation and remodeling
in COPD. Improving our knowledge of the mediators controlling cellular
migration, proliferation, differentiation, and matrix production should lead
to insights into new therapeutic approaches.
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