Biomedical Engineering Reference
In-Depth Information
The diversity of in vitro models, animal models, and human studies have led
to conflicting results regarding the importance of various components of the
inflammatory response. However, there is a cogent proof that NE is an early
step in a proteinase cascade, which leads to a local proteinase-antiprotei-
nase imbalance, causing tissue damage.
REFERENCES
1. Saetta MTG, Facchini FM, Corbino L, Lucchini RE, Casoni G, Maestrelli P,
et al. Inflammatory cells in the bronchial glands of smokers with chronic bron-
chitis. Am J Respir Crit Care Med 1997; 156:1633-1639.
2. Rutgers SR, Timens W, Kaufmann HF, van der Mark TW, Koeter GH,
Postma DS. Comparison of induced sputum with bronchial wash, bronchoal-
veolar lavage and bronchial biopsies in COPD. Eur Respir J 2000; 15:109-115.
3. Stanescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM, et al.
Airways obstruction, chronic expectoration and rapid decline in FEV1 in
smokers are associated with increased levels of sputum neutrophils. Thorax
1996; 51:267-271.
4. Martin TR, Raghu G, Maunder RJ, Springmeyer SC. The effects of chronic
bronchitis and chronic air flow obstruction on lung cell populations recovered
by bronchoalveolar lavage. Am Rev Respir Dis 1985; 132:260.
5. Ekberg-Jansson A, Andersson B, Bake B, Boijsen M, Enanden I, Rosengren
A, et al. Neutrophil associated activation markers in healthy smokers relates
to a fall in DLCO and to emphysematous change on high resolution CT.
Respir Med 2001; 95(5):363-373.
6. Burnett D, Chamba A, Hill SL, Stockley RA. Neutrophils from subjects with
chronic obstructive disease show enhanced chemotaxis and extracellular pro-
teolysis. Lancet 1987; 2:1043-1046.
7. Noguera A, Batle S, Miralles C, Iglesias J, Busquets X, MacNee W, et al.
Enhanced neutrophil response in chronic obstructive pulmonary disease.
Thorax 2001; 56:432-437.
8. YoshiokaA, BetsuyakuT, NishimuraM,MiyamotoK, KondoT, Kawakami Y.
Excessive neutrophil elastase in bronchoalveolar lavage fluid in subclinical
emphysema. Am J Respir Crit Care Med 1995; 152:2127-2132.
9. Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, et al.
Neutrophil granule proteins in bronchoalveolar lavage fluid from patients
with subclinical emphysema. Am J Respir Crit Care Med 1999; 159:
1985-1991.
10. Ge YM, Zhu YJ, Luo WC, Gong YH, Zhang XQ. Damaging role of neutro-
phil elastase in the elastic fiber and basement membrane in human emphyse-
matous lung. Chin Med J 1990; 103(7):588-594.
11. Fujita J, Nelson NL, Daughton DM, Dobry CA, Spurzem JR, Irino S, et al.
Evaluation of elastase and antielastase balance in patients with chronic bron-
chitis and pulmonary emphysema. Am Rev Respir Dis 1990; 142:57-62.
12. Finlay GA, ODeiscoll, Russell KJ, DArcy EM, Masterson JB, Fitzgerald
MX, O Connor CM. Matrix metalloproteinases expression and production
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