Biomedical Engineering Reference
In-Depth Information
Figure 1
The presumed signaling mechanisms of CXCL8.
towards sputum was reduced by 30% and 50%, although these effects were
not completely additive (71,72). Studies have not yet assessed the contribu-
tion of other potential chemoattractants such as GRO
a
or C5a.
IV. EPITHELIAL
=
ENDOTHELIAL CELLS AND NEUTROPHIL
CHEMOTAXIS
A. Neutrophil Migration into the Lung
Most of what we understand of neutrophil migration has been elucidated
from studies in vitro, using systemic vessels in the mesentery and dermis.
Recent work in lung suggests that although migration in postcapillary
venules occurs in a similar fashion to migration in other tissues, migration
in the pulmonary capillaries may depend on other mechanisms. In larger
