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3. Allowing the animal to linger outside the corner apparatus for
an additional 30 s, this can increase the exploratory activity
upon returning the rodent into the corner.
4. Try to simulate somatosensory cues by equally touching side-
to-side with a soft Q-tip applicator from distal approach.
5. Gently tap the tail, or slowly move the corner toward the ani-
mal to encourage turning and rearing around.
Although this unskilled task does not require pretraining, some
animals will present with baseline directional turning preferences,
and should be pretested to thereby be further excluded from
testing.
4.5. Pretesting
Other commonly used tests for assessment of functional recovery
after ICH in rodents include FUA (cylinder test) and forelimb
placing. These methods are discussed in other chapters.
4.6. Alternative
Neurobehavioral
Methods
References
1. Skriver EB, Olsen TS (1986) Tissue damage at
computed tomography following resolution of
intracerebral hematomas. Acta Radiol Diagn
(Stockh) 27:495-500
2. Broderick JP, Adams HP Jr, Barsan W, Feinberg
W, Feldmann E, Grotta J, Kase C, Krieger D,
Mayberg M, Tilley B, Zabramski JM, Zuccarello
M (1999) Guidelines for the management of
spontaneous intracerebral hemorrhage: a state-
ment for healthcare professionals from a special
writing group of the Stroke Council. American
Heart Association. Stroke 30:905-915
3. Xi G, Keep RF, Hoff JT (2006) Mechanisms of
brain injury after intracerebral haemorrhage.
Lancet Neurol 5:53-63
4. Stroke Therapy Academic Industry Roundtable
(STAIR) (1999) Recommendations for stan-
dards regarding preclinical neuroprotective and
restorative drug development. Stroke 30:
2752-2758
5. MacLellan CL, Silasi G, Poon CC, Edmundson
CL, Buist R, Peeling J, Colbourne F (2008)
Intracerebral hemorrhage models in rat: com-
paring collagenase to blood infusion. J Cereb
Blood Flow Metab 28:516-525
6. Zhang L, Schallert T, Zhang ZG, Jiang Q,
Arniego P, Li Q, Lu M, Chopp M (2002) A
test for detecting long-term sensorimotor
dysfunction in the mouse after focal cerebral
ischemia. J Neurosci Methods 117:207-214
7. Schallert T, Upchurch M, Lobaugh N, Farrar
SB, Spirduso WW, Gilliam P, Vaughn D, Wilcox
RE (1982) Tactile extinction: distinguishing
between sensorimotor and motor asymmetries
in rats with unilateral nigrostriatal damage.
Pharmacol Biochem Behav 16:455-462
8. Schallert T, Upchurch M, Wilcox RE, Vaughn
DM (1983) Posture-independent sensorimo-
tor analysis of inter-hemispheric receptor asym-
metries in neostriatum. Pharmacol Biochem
Behav 18:753-759
9. Hua Y, Schallert T, Keep RF, Wu J, Hoff JT, Xi
G (2002) Behavioral tests after intracerebral
hemorrhage in the rat. Stroke 33:2478-2484
10. Nakamura T, Xi G, Hua Y, Schallert T, Hoff
JT, Keep RF (2004) Intracerebral hemorrhage
in mice: model characterization and application
for genetically modifi ed mice. J Cereb Blood
Flow Metab 24:487-494
11. Warkentin LM, Auriat AM, Wowk S, Colbourne
F (2010) Failure of deferoxamine, an iron che-
lator, to improve outcome after collagenase-
induced intracerebral hemorrhage in rats. Brain
Res 1309:95-103
12. Schallert T (2006) Behavioral tests for preclinical
intervention assessment. NeuroRx 3:497-504
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