Biology Reference
In-Depth Information
Chapter 49
Intracranial Pressure Assessment
Yangdong He , Ya Hua , and Guohua Xi
Abstract
Intracranial pressure (ICP) monitoring is an important component of brain monitoring. Numerous methods
for measuring ICP in animal models have been described, including the use of epidural monitors and
subdural, ventricular, parenchyma, cisterma magna catheters, and lumbar cerebrospinal fl uid pressure.
The ventricular catheter method is considered to be the gold standard for measuring ICP. Here, we introduce
a method to monitor ICP in rats using an ultraminiature fi ber optic transducer placed into the lateral
ventricle. The details of procedures, along with applications, advantages, and limitations are discussed here.
Key words:
Intracranial pressure, Rat, Lateral ventricle
1. Introduction
Monitoring intracranial pressure (ICP) is a very important compo-
nent of brain monitoring and has been used in the study of many
neurosurgical and neurological disorders, including head injury,
intracerebral hemorrhage, subarachnoid hemorrhage, hydrocepha-
lus, brain ischemia, cerebral edema, brain tumor, central nervous
system infections, and hepatic encephalopathy (
1
). A number of
methods for measuring ICP in animal models have been described,
including the use of epidural monitors and subdural, ventricular,
parenchyma, cisterma magna catheters, and lumbar cerebrospinal
fl uid pressure (
2-7
). Among these methods, a ventricular catheter
connected to an external strain gauge transducers or catheter tip
pressure transducer device is considered to be the gold standard for
measuring ICP (
8
). In this chapter, we introduce a method to
monitor ICP in rats using an ultraminiature fi ber optic transducer
placed into the lateral ventricle.
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