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Fig. 9. Interface of the SPM software, which can be used for performing voxel-based morphometry (VBM). See Fig.
5
for a
sample VBM result.
(4) Run “Normalise” option to normalize gray matter maps to the
atlas space.
(5) Run “Smooth” option to smooth gray matter maps to increase
signal-to-noise ratio.
(6) Run “Specify 2nd-level” option to perform group statistical
analysis.
For more complicated operations, complete SPM documenta-
tion is available at
http://www.fi l.ion.ucl.ac.uk/spm/
.
7.3. Surface-Based
Morphometry
Besides VBM, other advanced computational neuroanatomical
techniques (
18
) are available for processing 3D image sets. While
VBM analyzes image volumes, SBM (
19
) focuses on the surface
representation of a structure and performs statistical analysis on a
surface manifold to capture structure changes related to different con-
ditions. Figure
6
shows the results of a sample SBM study, where
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