Neurobehavioral Assessments of Cerebral Vasospasm - Animal Models of Acute Neurological Injuries: Injury and Mechanistic Assessments - page 568

were often criticized as being inadequate to study vasospasm ( 50 ),
may be very helpful in studying mechanisms other than aSAH-
related vasospasm and help to elucidate their role in evoking neu-
robehavioral changes. Furthermore, neurobehavioral testing of
nonhuman primates after clot placement or other methods of SAH
can provide the best distinction between SAH- and vasospasm-
related neurobehavioral changes as well as be a reliable transla-
tional tool to address the changes observed in patients.
Nevertheless, several limitations of translating experimental results
to the patient population and vice versa have to be recognized early
and properly addressed while developing adequate models. Among
the crucial limitations is the vast diffi culty in studying early versus
delayed effects of SAH, their occurrence with or without vasospasm,
or behavioral effects of surgical versus endovascular intervention.
Although there are numerous potential limitations that must
be kept fi rmly in mind, we believe that systematic research with
animal models including non human primate model will continue
to play a critical role in understanding and assessing the effects of
cerebral vasospasm on cognitive and behavioral function to help
the patients like Ms. CD whose medical history provided inspira-
tion for this chapter.

Acknowledgement

This research was partially supported by the Intramural Research
Program of the NIH, NINDS.

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