Neurobehavioral Assessments of Cerebral Vasospasm - Animal Models of Acute Neurological Injuries: Injury and Mechanistic Assessments - page 548

Table 8
Possible neuropsychological and psychopathological
changes after aSAH (modifi ed after Hutter ( 44 ) )
Visual fi eld defects
Neglect
Defects of visual and spatial constructive capacities
Distortions of face and object recognition
Memory disorders
Language disturbances (aphasias)
Defi cits in problem solving
Apraxias
Attention defi cits
Mental rigidity
Dementia
Defi cits of concentration capacity
Personality changes/emotional disorders
Behavioral disorders
Organic personality disorder
Apathy and loss of interest
Impairment of social judgment
Aggressiveness or rage
Affect lability, disinhibition, and/or syndrome (depression)
Organic psychosocial maladjustment
assessment of neurobehavioral changes after aSAH becomes a rou-
tine outcome measure. The next table (Table 8 ; after Hutter ( 44 ))
summarizes the neurobehavioral changes that were reported in
patients after aSAH and treatment of aneurysms that should be
addressed by the animal models.
This list of neurobehavioral changes after aSAH is a basis for
the animal tests (presented in Table 9 ) to assess the neuropsy-
chological and neurobehavioral changes. We also describe their
applicability to the existing SAH models and propose adequate
model(s) to study aSAH-related mechanisms infl uencing behav-
ioral and neurological outcomes.