Assessment of Intracellular Calcium in Cerebral Artery Myocytes - Animal Models of Acute Neurological Injuries: Injury and Mechanistic Assessments - page 537

of choice for measurement of global cytosolic Ca 2+ , or averaged
Ca 2+ levels throughout the cytoplasm. On the other hand, transient
Ca 2+ release events from the SR (Ca 2+ sparks) require the use of
single-wavelength Ca 2+ indicators such as fl uo-4. A thorough
knowledge of these Ca 2+ signaling processes is imperative for under-
standing mechanisms contributing to cerebral vascular pathologies
such as subarachnoid hemorrhage.

Acknowledgements

This work was supported by the Totman Medical Research Trust
Fund, the Peter Martin Brain Aneurysm Endowment, the NIH
(NIHLBI, R01 HL078983, HL078983-05S1 and NCRR, P20
RR16435) and the American Heart Association (0725837T,
0815736D). The authors wish to thank to Dr. Adrian Bonev for
his helpful comments and suggestions. The authors would also like
to acknowledge the University of Vermont Neuroscience COBRE
imaging core facilities.

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