Biology Reference
In-Depth Information
3.4. Climbing
1. Place an animal on the slop.
2. Observe the climbing.
3. Note the strength of attachment when the animal is removed
from the slop by pulling it off by the tail.
4. Scores indicate the following:
3, rat climbs easily and grips tightly to the slop the same as
presurgery.
2, rat climbs less easily compared with presurgery.
1, rat fails to climb or tends to circle instead of climbing.
0, rat cannot stay on the slop more than 1 min.
3.5. Body
Proprioception
1. Touch a body with a blunt stick on each side of the body.
2. Observe the reaction to the stimulus.
3. Scores indicate the following:
3, rat reacts by turning the head and is equally startled by the
stimulus on both sides.
2, rat reacts slowly to stimulus on either or both sides.
1, rat does not respond to the stimulus on either or both sides.
1. Brush a blunt stick against the vibrissae on each side; move the
stick toward the whiskers from the rear of the animal to avoid
entering the visual fi elds.
2. Scores indicate the following:
3, rat reacts by turning the head or is equally startled by the
stimulus on both sides.
2, rat reacts slowly to stimulus on either or both sides.
1, rat does not respond to stimulus on either or both sides.
3.6. Response to
Vibrissae Touch
3.7. Presenting
the Score
1. Sum up all six individual test scores; the minimum neurological
score is 2 and the maximum is 18.
4. Notes
4.1. When to Assess
the Modifi ed Garcia's
Score After SAH
The Garcia's scoring system with or without a modifi cation has
been demonstrated to be applicable as early as 6 h and as late as
72 h after SAH ( 7, 8 ). However, the best time points are 24, 48,
or 72 h after SAH depending on treatment regimens. This score
can be assessed anytime, and differentiate SAH animals from sham-
operated animals even at 6 h after SAH. However, when this score
is assessed within 24 h after SAH, it is often diffi cult to detect treat-
ment effects because of the initial impact of SAH or the infl uence
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