Electrophysiology and Morris Water Maze to Assess Hippocampal Function After Experimental Subarachnoid Hemorrhage - Animal Models of Acute Neurological Injuries: Injury and Mechanistic Assessments - page 402

the MWM ( 22 ). A spatial acquisition task can be performed for 4
B 14 days. Trial number can be varied from 4 to 16 trials per day
with each trial lasting anywhere from 60 to 90 s ( 24, 25 ).
Relearning can be induced and assessed by keeping the plat-
form location same in the spatial acquisition task and changing it
to a novel location in the second series of trials (relearning phase)
which is performed at a minimum of ~1 week (rest period) after
the spatial acquisition task. The rest of the procedure is the same.

Spatial test can be performed anywhere from 3 days to 5 weeks
after SAH ( 24, 25 ).

5.2. When to Perform
Morris Water Maze
After SAH?

Different mazes, such as radial arm, the 3-door runway, T and Y
maze, offer a variety of methods to assess learning and memory
( 26 ). However, the MWM is believed to be one of the more reli-
able methods and is commonly used to test spatial memory in rats
and mice.

5.3. Alternative
Methods to Examine
Hippocampal Function

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