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to use other markers for thromboemboli that detect molecules or
their epitopes that are present only in clot.
4.3. Alternative
Methods for the
Measurement of
Microthrombo-
embolism
Stein et al. (
5
) identifi ed microthromboemboli in histological
sections of human brains obtained at autopsy from patients
dying of SAH. Primary antibodies to antithrombin III were used,
which would detect free antithrombin III as well as antithrombin
III bound in protease complexes. Microthrombus formation
has been assessed by intravital microscopy in a variety of condi-
tions including after traumatic brain injury in mice (
10
). This
method might be valuable for determining if the clots are emboli
or thrombi.
References
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