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are responsible for the observed defi cits. Although certain brain
regions appear to be especially vulnerable to TBI, no single brain
region is responsible for the cognitive dysfunction observed following
trauma.
The MWM spatial navigation task has been by far the most
extensively used cognitive assessment for investigating memory
dysfunction following injury. Although it has many advantages and
has allowed for the generalization of results across different labora-
tories, it involves more than one type of learning and does not
allow for a full understanding of the nature of cognitive dysfunc-
tion following injury, specifi cally the different types of information
processing. Other cognitive assessments have been explored following
experimental injury in order to offer a variety of behavioral
outcome measures that are sensitive to multiple types of memory
dysfunction. However, for many of these procedures, standard
protocols have not yet been established or verifi ed in different
experimental injury models. Even slight differences in methodology
may produce dramatic differences in cognitive outcome. This chapter
has described both the most standard cognitive assessments used
following experimental injury and some other experimental
paradigms that expand the understanding of the types of memory
dysfunction observed following TBI.
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