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suggests low release probability because the fi rst AP depletes
readily releasable pool of vesicles less.
4. Baseline response in LTP and LTD recording:
It is important to obtain a stable baseline recording of fEPSPs
before induction of LTP or LTD. If systematic change in
fEPSPs is observed, baseline recording should be continued
until a stable baseline level is achieved.
5. Monitoring recording condition:
Because recording of LTP and LTD can take a few hours, it is
important to monitor any potential changes in recording
conditions. One method is to compare stimulus artifact and
the amplitude of compound APs between before and after LTP
or LTD induction. No signifi cant changes in both suggest
stable and acceptable recordings.
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