Physiological Assessment in Stroke Research - Animal Models of Acute Neurological Injuries: Injury and Mechanistic Assessments - page 84

in these vessels refl ects the blood fl owing through them (with spatial
resolution of >1 mm and temporal resolution of 10 s). The draw-
back is that the brain has to be destroyed to collect the microsphere
to count for radioactivity. Later, radiolabeled microspheres were
replaced with nonfl uorescent and fl uorescent dye-fi lled micro-
spheres which allow easier detection of blood fl ow levels compared
to the use of radioactive microspheres ( 43 ).

References

1. Mackay J et al (2004) The atlas of heart disease
and stroke. World Health Organization,
Geneva, p 112
2. Lloyd-Jones D et al (2009) Heart disease and
stroke statistics—2010 update. A Report from the
American Heart Association. Circulation, 2009
3. American Heart Association (1999) Heart and
stroke statistical update. American Heart
Association, Dallas, TX
4. Zaleska MM et al (2009) The development of
stroke therapeutics: promising mechanisms
and

14. Buchan A, Pulsinelli WA (1990) Hypothermia
but not the N-methyl-D-aspartate antagonist,
MK-801, attenuates neuronal damage in ger-
bils subjected to transient global ischemia. J
Neurosci 10(1):311-316
15. Adams HP Jr et al (2007) Guidelines for the
early management of adults with ischemic
stroke: a guideline from the American Heart
Association/American Stroke Association
Stroke Council, Clinical Cardiology Council,
Cardiovascular Radiology and Intervention
Council, and the Atherosclerotic Peripheral
Vascular Disease and Quality of Care Outcomes
in Research Interdisciplinary Working Groups:
the American Academy of Neurology affi rms
the value of this guideline as an educational
tool

translational challenges. Neuro-

pharmacology 56(2):329-341
5. Suwanwela N, Koroshetz WJ (2007) Acute
ischemic stroke: overview of recent therapeutic
developments. Annu Rev Med 58:89-106
6. Wiebers DO, Adams HP Jr, Whisnant JP
(1990) Animal models of stroke: are they rel-
evant to human disease? Stroke 21(1):1-3
7. Fischer M (1999) Recommendations for stan-
dards regarding preclinical neuroprotective
and resotative drug development. Stroke
30:2752-2758
8. Philip M et al (2009) Methodological quality
of animal studies of neuroprotective agents
currently in phase II/III acute ischemic stroke
trials. Stroke 40(2):577-581
9. Molinari GF (1988) Why model strokes?
Stroke 19(10):1195-1197
10. Johnston KC et al (2009) Glucose regulation in
acute stroke patients (GRASP) trial: a random-
ized pilot trial. Stroke 40(12):3804-3809
11. Potter JF et al (2009) Controlling hyperten-
sion and hypotension immediately post-stroke
(CHHIPS): a randomised, placebo-controlled,
double-blind pilot trial. Lancet Neurol
8(1):48-56
12. Anderson CS et al (2008) Intensive blood
pressure reduction in acute cerebral haemor-
rhage trial (INTERACT): a randomised pilot
trial. Lancet Neurol 7(5):391-399
13. Wang CX et al (2009) Hyperthermia exacer-
bates ischaemic brain injury. Int J Stroke
4(4):274-284

for neurologists. Stroke

38(5):1655-1711
16. Broderick J et al (2007) Guidelines for the
management of spontaneous intracerebral
hemorrhage in adults: 2007 update: a guide-
line from the American Heart Association/
American Stroke Association Stroke Council,
High Blood Pressure Research Council, and
the Quality of Care and Outcomes in Research
Interdisciplinary Working Group. Stroke
38(6):2001-2023
17. Hoyt R et al (2007) Mouse physiology. In:
Fox J, Barthold SW, Davisson MT, Newcomer
CE, Quimby FW, Smith AL (eds) The mouse
in biomedical research, vol 3, 2nd edn. Elsevier,
Burlington, MA
18. Swoap SJ, Overton JM, Garber G (2004)
Effect of ambient temperature on cardiovascu-
lar parameters in rats and mice: a comparative
approach. Am J Physiol Regul Integr Comp
Physiol 287(2):R391-R396
19. Dirnagl U (2006) Bench to bedside: the quest
for quality in experimental stroke research. J
Cereb Blood Flow Metab 26(12):1465-1478
20. Liu S et al (2009) Rodent stroke model guide-
lines for preclinical stroke trials (1st edition). J
Exp Stroke Transl Med 2(2):2-27
21. Mills PA et al (2000) A new method for mea-
surement of blood pressure, heart rate, and