Biomedical Engineering Reference
In-Depth Information
Table 13.1
Human gene transfer protocols submitted to the Office of Recombinant DNA
Activities, U.S. National Institutes of Health, 1988-2003
Year
Protocols
1988
1
1989
0
1990
2
1991
9
1992
24
1993
31
1994
31
1995
44
1996
28
1997
56
1998
51
1999
91
2000
71
2001
73
2002
51
2003*
18
* Through June 10
The variations in the numbers of research protocols submitted
annually to the NIH are displayed graphically in Figure 13.1. These
research protocols can be subdivided into various categories:
By major type
•
Disease-oriented studies: 523
•
Gene-marking studies: 41
•
Nontherapeutic studies: 5
By disease target in the disease-oriented studies
•
Cancers of various kinds: 367 (70.2 percent)
•
Single-gene disorders: 57 (10.9 percent)
•
Other diseases or disorders: 60 (11.5 percent)
•
Infectious diseases: 39 (7.5 percent)
By disease, among the most frequently targeted single-gene disorders
•
Cystic fibrosis: 23
•
Severe combined immunodeficiency: 6
•
Hemophilia: 5
