Enzymatic Modification and Polymerization of Siloxane-Containing Materials - Bio-Inspired Silicon-Based Materials - page 85

PJ PJ PJ

Eϰϯϱ>ŽĂĚŝŶŐ

Ϯϱ

ϮϬ

ϭϱ

ϭϬ

ϱ

Ϭ

ϮϰŚ ϰϴŚ

dŝŵĞ

Fig. 6.9 Top panel : The enzymatic hydrolysis of 3AcO-TMDS. Hydrolysis is proportional to
enzyme loading. Bottom panel : Increased reaction time leads to an increase in hydrolysis. In the
absence of N435 hydrolysis is not observed

We have presented some of our work using N435 as a catalyst for preparing
polyesters containing disiloxane and polysiloxane blocks, and for the preparation of
organosilicon reagents containing a disiloxane framework. N435 accepted the disi-
loxane derived acyl donor, CPr-TMDS-DME; however when compared substrates
which mimic the natural substrate for this enzyme, the disiloxane diester was not
processed as quickly. Our results suggest that there lack of rotational freedom may
be a limiting factor in this, but a steric contribution cannot be eliminated. While