Biomedical Engineering Reference
In-Depth Information
Fig. 8
Effect of Ceramide C10 on UACC 933 melanoma cells.
The cell death of UACC 933
melanoma cells is induced (
b
) by treatment with decanoyl-ceramide (Cer
10
) rhodamine
WT-calcium phosphosilicate nanoparticles (CPSNPs) when compared to (
a
) the treatment with
control calcium phosphate nanoparticles. (
c
) An MTS cytotoxicity assay demonstrates dosage
dependent cell death for Cer
10
CPSNPs in UACC 903 cells (Reproduced from Kester (
2008
). With
permission)
on these results, CPSNPs could be further investigated
in vivo
for the delivery of
other hydrophobic chemotherapeutics, especially using similar synthetic
approaches where the drug is shielded from degradation via encapsulation inside
the nanoparticles.
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