Biomedical Engineering Reference
In-Depth Information
Fig. 9 THz images of cancerous tumors and organs. ( a ) From a mouse with the injection of
nanoprobes; ( b ) from a mouse without the injection
5
Conclusion
The principle of TMI is presented along with a brief review of the method of genera-
tion and detection of THz waves. The use of the TMI technique enables the quantitative
measurement of nanoparticle distributions and allows for the high-contrast imaging of
these distributions. The effectiveness of this technique is demonstrated by considering
nanoprobe delivery to a cancerous tumor and the organs in a mouse. The images show
that the signal amplitudes are linearly proportional to the nanoprobe concentration
(Oh et al. 2011 ). The TMI technique has promising applications in the target-specific
sensing of cancers as well as in the molecular diagnosis of drug delivery.
Acknowledgments The authors thank Mr. Heejun Shin and Mr. Dong-Gyu Lee for their
assistance in the preparation of this paper. This study was supported by a grant from the Korean
Health Technology R&D Project of the Ministry for Health, Welfare and Family Affairs, Republic
of Korea (A101954), and a National Research Foundation of Korea (NRF) grant funded by
the Korean government (MEST) under Grant Nos. 20100020647, 20100001979, 20100015989,
20100011934, and 20090054519.
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