Non-viral Gene Therapy - Intracellular Delivery: Fundamentals and Applications - page 613

Table 2 Various chemical modifications on PLL
Molecules used for modifications Reference

Incani et al.
( 2009 )

O

OH

Caprylic acid

O Incani et al.

( 2009 )

OH

Myristic acid

O

Incani et al.
( 2007 )

OH

Palmitic acid

O Incani et al.

( 2009 )

OH

Stearic acid

Incani et al.
( 2009 )

O

OH

Oleic acid

O

Incani et al.
( 2009 )

OH

Linoleic acid

CH 3

Jeon et al.
( 2003 )

O

O

HO O OH

n n

m

Pluronic

Katayose and
Kataoka
( 1997 )

O

HO OH

n

PEG

delivering plasmid DNA (pDNA) into bone marrow stromal cells (Incani et al.
2007 ). Compared with the precursor PLL, the transfection efficiency of PLL-PA
was greatly enhanced (~5-fold). PLL-PA was also found to be able to effectively
deliver pDNA into human skin fibroblasts in vitro , which was more efficient than
that of PEI, Lipofectamine 2000, and even an adenovirus employed by the same
researchers (Abbasi et al. 2007 ). Lipid-substituted PLLs were also synthesized