Nanoparticles Enhanced Hyperthermia - Intracellular Delivery: Fundamentals and Applications - page 578

Table 2 Several clinical studies on magnetic nano-hyperthermia

Temperature
measurement

First
therapy Tumor cells IAMFL (mL) NOT NOP T max (°C) TS Result Reference

Prostate 11.4 (4-14) 6 10 42.7 (40.5-51.3) 15.8 (1.6-45.3) - Fiberoptic thermometry

probes

Curative Johannsen et al.

( 2007a, b )

8.5 (6.0-12.5) 6 8 41.5 (40.9-45.4) 29.7 (15.9-48.7) - - R Wust et al. ( 2006 )

Glioblastoma (4.5, 4.6) 6 2 (49.5, 65.6) (36.3, 50) DOD Fiberoptic thermometry

probes

S + R+C van Landeghem

et al. ( 2009 )

0.2 (0.1-0.7) 6(4-10) 14 44.6 (42.4-49.5) 12.1 (4-41.2) 4DWD Fiberoptic thermometry

probes

S + C Maier-Hauff

et al. ( 2007 )

9DOD
1Alive
DOD dead of disease, DWD dead without disease, NOT number of treatment, NOP number of patients, IAMFL injected amount magnetic fluid, TS tumor size,
S surgery, R radiotherapy, C chemotherapy