Nanoparticles Enhanced Hyperthermia - Intracellular Delivery: Fundamentals and Applications - page 569

joining along this research direction. Meanwhile, other heating approaches such as
near infrared and laser, etc., are also being tried in order to establish new nano
hyperthermia approach.
In tumor hyperthermia, the major target is to deliver energy to tumor to improve
its temperature. Up to now, various heating methods have been developed, such
as RF, MW and laser heating, etc. (Fig. 1 ). As is well known, when the size of
a kind of material reduces to nano-level, its properties in electronic, magnetic,
acoustics, optics, thermal and chemical properties will change. Therefore, suitable
nanoparticles can help improve the effect of specific means of traditional tumor
hyperthermia.
In this chapter, we mainly review the nanoparticles enhanced magnetic, optical
and RF hyperthermia, and discuss several possible methods in ultrasound, thermal
chemical hyperthermia and direct heat delivery hyperthermia, then analyze several
challenges in developing nanoparticle enhanced hyperthermia, such as particle
delivery, monitoring, combined effects with radiotherapy and chemotherapy, etc.
Fig. 1 Typical heating strategies for tumor thermal ablation