Nanoparticles for Photodynamic Therapy Applications - Intracellular Delivery: Fundamentals and Applications - page 557

therapeutic approaches have involved the systemic administration of cytotoxic
drugs, focal therapy such as PDT allows for real control of the localization of the
therapeutic effect.

8 Conclusion

Simple and proper methodologies to develop formulations of nanoparticles appli-
cable for PDT applications are currently being developed. Depending of the syn-
thetic method, nanoparticles of different controlled size, porosity and properties can
be elaborated. Moreover, addition of cancer biomarkers can guide the particle to
specifically targeted cancer cells resulting in less damage of healthy cells. Recent
developments concern the use of silica nanoparticles that can be excited by IR or
two-photon in order to treat tissues more deeply. New researches are also focused
on multifunctional nanoparticles that could serve both as diagnosis tools and thera-
peutic agents. Thus, we believe that nanoparticles gathering (ii) covalent coupling
of the photosensitizer, (ii) specific core that allow for example MRI for diagnosis
or drug encapsulation and (ii) a vector may be an important advancement for the
future of PDT.

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