Biomedical Engineering Reference
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Fig. 44
(N,N¢)-bis(2-6-
dimethylphenyl)perylene-
3,4,9,10-tetracarbodiimide
(DXP)
O
O
N
N
O
O
Fig. 45
Phthalocyaninedihy
droxyle (PC)
N
N
N
HO
N
Si
N
OH
N
N
N
Hocine et al.
(doi:
10.1016/j.ijpharm.2010.10.004
) described the preparation of
silicalite (crystalline silica zeolite) nanoparticles with diameters below 100 nm.
Those nanoparticles covalently encapsulated water-soluble porphyrins, at low
amount inside the silica matrix. Those nanoparticles were able to generate singlet
oxygen. After incubation of the silicalite nanoparticles with MDA-MB-231 breast
cancer cells for 24 h, and irradiation with red light (650 nm), significant cancer cell
death (45-50%) was observed.
7.4
Iron Oxide (Fe
3
O
4
)
Macrophage has emerged as a key biological, imaging and therapeutic target for
atherosclerosis and antimacrophage therapeutic strategies are becoming prevalent.
Among them, the team of McCarthy et al. (
2006, 2010
) used systemic modulation
of macrophage activity and localized PDT. They described in 2006 the synthesis
and biological study of dextran-coated magnetofluorescent nanoparticles conju-
gated to 5-(4-carboxyphenyl)-10,15,20-triphenyl-2,3-dihydrochlorin (Fig.
46
) as a
photosensitizer and Alexa Fluor 750 as a fluorophore. Cellular uptake and light-
induce phototoxicity were investigated in both the RAW 264.7 murine macrophage
cell line and transformed human macrophages (U937 cells). These nanoobjects
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