Biomedical Engineering Reference
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Fig. 39
PS used by Erbas
et al.
N
Peg
2000
N
N
O
I
I
N
B
N
FF
O
O
(H
2
C)
6
(CH
2
)
6
O
O
aptamers toward one biological target, and the quenching efficiency of the probe
are many qualities to make out a relevant PDT agent.
In a recent paper, Erbas et al. (
2009
) developed non-covalent functionalized
SWNTs as delivery agents for novel bodipy-based potential PDT photosensitizers.
Their molecule was composed of PEG2000, distyryl-bodipy, intersystem crossing
promoter heavy atoms (iodines at 2 and 6 positions of the bodipy core) and 2 pyrene
subsituents for-p stacking interactions with the SWNTs (Fig.
39
). A low decrease
of
1
O
2
production of the compound non covalently attached to the SWNT was
observed, compared to the free one.
Even more recently, do Nascimento et al. (
2010
) modified SWNTs with organic
dyes such as phenosafranine and Nile Blue (Figs.
40
and
41
) that can act as photo-
sensitizers in energy and electron transfer reactions to be applied in PDT. The
authors realized a covalent assembly between SWNTs that have been oxidized to
introduce COOH groups and the photosensitizers. Cytotoxicity and photocytoxicity
effects were tested on BHK-21 cell line from mouse fibroblasts. The data for dye-
modified SWNT composites in the presence or absence of light show that the
SWNT-Nile Blue (4 mg/mL) composite described photodynamic efficiency and a
reduced dye photobleaching by auto-oxidation.
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