Nanoparticles for Photodynamic Therapy Applications - Intracellular Delivery: Fundamentals and Applications - page 537

SO 3

NH N

O 3 S NHCONH(CH 2 ) 3 Si(OEt) 3

N HN

SO 3

Fig. 27 Water-soluble porphyrin (Reproduced by permission of The Royal Society of Chemistry)

Fig. 28 APTS-HP
(Reproduced by permission
of The Royal Society of
Chemistry)

OH

NH N

OH

N HN

(EtO) 3 Si Si(OEt) 3

matrix and targeting of cancer cells with mannose attached on the surface of MSN.
Targeting breast cancer cells (MDA-MB-231) with mannose was essential to get a
high PDT efficiency. Indeed the involvement of mannose receptors in the active
endocytosis of mannose-functionalized MSN was demonstrated.
In the promising field of using silica nanoparticles as multifunctional platform
for imaging and therapy, Zhang et al. ( 2009 ) described the synthesis of a highly
efficient multifunctional nanocomposite material that contains both a nonporous
FITC-doped silica core for fluorescence imaging and a mesoporous silica shell
containing hematoporphyrin (HP) as a photosensitizer. Non porous FITC@SiO 2
core were synthesized via a water-in-oil reverse microemulsion. The hematopor-
phyrin conjugated mesoporous silica nanoparticles were synthesized with TEOS
and APTS-HP (Fig. 28 ) via a sol-gel O/W co-condensation reaction. The non
porous silica core isolated the fluorescent dye from the external environment to