Biomedical Engineering Reference
In-Depth Information
Nanoparticles for Photodynamic
Therapy Applications
Régis Vanderesse, Céline Frochot, Muriel Barberi-Heyob,
Sébastien Richeter, Laurence Raehm, and Jean-Olivier Durand
Abstract
Photodynamic therapy has emerged as an alternative to chemo- and
radiotherapy for the treatment of certain types of cancer. Nanoparticles have been
used to improve the delivery and the efficiency of the photosensitizer as they allow
its encapsulation without loss of activity. Using targeting strategies, they can also
allow the selective accumulation of the photosensitizer in the cancer tissues. In this
review, based on the chemical nature of the nanoparticles, the different methods
for their syntheses are described from the pioneering works to the latest achieve-
ments. Indeed the nanosystems can be conjugated to a biomolecule or an antibody
to target receptors over-expressed in cancer cells and/or angiogenic vascular
endothelial cells. Numerous
in vivo
and
in vitro
applications have been described.
Multifunctional nanoplatforms combining several applications within the same
nano-object emerge as potential important theranostic tools.
Keywords
Nanoparticles
•
Photosensitizers
•
Photodynamic therapy
•
Reactive
oxygen species
•
Nanomedicine
R. Vanderesse
Laboratoire de Chimie-Physique Macromoléculaire, UMR CNRS-INPL 7568, Nancy Université,
1 rue Grandville, BP20451, 54001 Nancy Cedex, France
C. Frochot
Laboratoire Réactions et Génie des Procédés, UPR 3349, Nancy-Université,
1 rue Grandville, BP20451, 54001 Nancy Cedex, France
M. Barberi-Heyob
Centre de Recherche en Automatique de Nancy (CRAN), UMR 7039,
Nancy-Université, CNRS, Centre Alexis Vautrin Brabois, Avenue de Bourgogne,
54511 Vandoeuvre-les-Nancy Cedex, France
S. Richeter, L. Raehm (
*
), and J.-O. Durand
Equipe Chimie Moléculaire et Organisation du Solide, Institut Charles Gerhardt
Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, CC1701 Place Eugène Bataillon,
34095, Montpellier Cedex 05, France
e-mail: lraehm@univ-montp2.fr
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