Biomedical Engineering Reference
In-Depth Information
Processing and Scale-up of Polymeric
Nanoparticles
Christine Vauthier and Kawthar Bouchemal
Abstract
This chapter presents methods of nanoparticle processing based on
the use of preformed polymers. It will discuss the basic principle of the different
methods, the scale up and the methods for preparing the polymer nanoparticles for
storage including purification, drying sterilization and eventually concentration.
The last part of the chapter will discuss the performance, the application and the
present limitation of the processing methods considered here.
Keywords
Emulsification-solvent diffusion
•
Emulsification-solvent evaporation
•
Gelation
•
Nanocapsules
•
Nanoprecipitation
•
Nanospheres
•
Polymer micelles
•
Scale-up
Abbreviations
ACN
acetonitrile
CMC
critical micellar concentration
DMAc
N-N-dimethylacetamide
DMF
dimethylformamide
O/O
Oil in oil emulsion
O/W
oil in water emulsion
PEC
polyelectrolyte complexes
PEG
poly(ethylene glycol)
PEI
poly(ethylenimine)
C. Vauthier (
*
)
Physico-chimie, Pharmacotechnie, Biopharmacie, Univ Paris-Sud, UMR 8612,
F-92296 Chatenay-Malabry, France
and
CNRS, Chatenay-Malabry F-92296, France
e-mail: christine.vauthier@u-psud.fr
K. Bouchemal
Physico-chimie, Pharmacotechnie, Biopharmacie, UMR CNRS 8612, Univ Paris-Sud,
F-92296 Chatenay-Malabry, France
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