Nanocrystals: Production, Cellular Drug Delivery, Current and Future Products - Intracellular Delivery: Fundamentals and Applications - page 417

Solvent and non-solvent are pumped via separate tubes into the static blender.
The blender contains buffles leading to fast blending and precipitation. The system
can be run continuously from two supply containers (Fig. 2 , upper).
Fig. 2 Large scale production of nanocrystals (explanations cf. text): upper - solvent with drug
and non solvent are mixed in a static blender; middle - macrosuspension is passed multiply from
two containers through a bead mill; lower - four homogenizers in line for nanocrystal production,
one pass is equivalent to four homogenization cycles