Mass Transport via Cellular Barriers and Endocytosis - Intracellular Delivery: Fundamentals and Applications - page 22

Table 1 (continued )

Receptor Ligand Target cells Nanovector Mechanism References

GRP-78 WIFPWIQL Breast and prostate

tumor cells

PEG-PAMAM Receptor mediated

endocytosis

Wood et al. ( 2008 )

CAYHRLRRC Leukemia and

Lymphoma cells

Macropinocytosis Nishimura et al. ( 2008 )

Vascular (atherosclerosis, atherothrombosis, etc.)
VCAM-1

VCAM-1 Antibody Endothelial cells

(cerebral)

Microparticles of iron
oxide

McAteer et al. ( 2007 )

P-selectin + VCAM-
1

P-selectin and
VCAM-1
antibodies

Atherosclerotic plaque
endothelium

Microparticles of iron
oxide

McAteer et al. ( 2008 ) and
Ye et al. ( 2008 )

GPIIb/IIIa receptor LIBS antibody Activated platelets Microparticles of iron

oxide

Stoll et al. ( 2007 ) Schwarz
et al. ( 2006 ), and
Schwarz et al. ( 2004 )

HIV
Con A Mannose Macrophage like cells

(HIV targeting)

Liposomes, gelatin
nanoparticles,
dendrimers

Garg et al. ( 2006 ), Jain et al.
( 2008 ), and Dutta and
Jain ( 2007 )

HIV-1 BAL gp120 Aptamer targeting

gp120

HIV, T-cells and
PBMC

Aptamer-siRNA Receptor mediate

endocytosis

Zhou et al. ( 2009 )

Lung

CGSPGWVRC Lung endothelial

cells

Peptide - (KLAKLAK) D
conjugate

Giordano et al. ( 2008 )

Fat
Prohibitin

CKGGRAKDC Adipose tissue

endothelial cells

Peptide - (KLAKLAK) D
conjugate

Kolonin et al. ( 2004 )

AAVP adeno-associated virus/phage, LHRH leutinizing hormone releasing hormone, PEG poly ethylene glycol, LDL low density lipoprotein, PLGA poly
(lactide-co-glycolide), PSMA prostate specific membrane antigen, GRP-78 glucose regulated protein 78, VCAM vascular cell adhesion molecule, GP glyco-
protein, HIV human immunodeficiency virus, PBMC peripheral blood mononuclear cells