Mass Transport via Cellular Barriers and Endocytosis - Intracellular Delivery: Fundamentals and Applications - page 21

Table 1 Examples of receptors used for internalization of nanoparticles
Receptor Ligand Target cells Nanovector Mechanism References

Cancer therapeutics
a v b 3 Integrin

RGD-4C Tumor cells Hybrid viral particles

called AAVP

Receptor mediated
endocytosis

Pasqualini et al. ( 1997 ) and
Hajitou et al. ( 2006 )

LHRH receptor LHRH peptide Ovarian, breast and

prostate tumor cells

Campothecin-PEG-LHRH Dharap et al. ( 2005 )

Folate receptor Folic acid Tumor cells Doxorubicin/antisense

oligonucleotides
against EGFR
loaded liposomes

Receptor mediated
endocytosis

Guo et al. ( 2000 ),
Leamon and Low ( 1991 ),
Pan et al. ( 2003 ), and
Wang et al. ( 1995 )

LDL receptor Poloxamer 188 Brain blood vessel

endothelial cells

Doxorubicin loaded
PLGA nanoparticles

Phagocytosis Gelperina et al. ( 2010 )

Aminopeptidase N NGR peptide Tumor endothelial

cells

Liposomes, phage Pasqualini et al. ( 2000 ) and

Loi et al. ( 2010 )

Transferrin receptor Transferrin Gastric and colon

cancer cells

Cisplatin containing PEG-
liposomes

Receptor mediated
endocytosis

Ishida et al. ( 2001 ) and
Iinuma et al. ( 2002 )

Insulin receptor Insulin Fibroblasts Superparamagnetic iron

oxide nanoparticles

Prevention of
endocytosis

Gupta et al. ( 2003 )

Vascular Endothelial
Growth Factor
receptor (FLK1)

Anti-Vascular
Endothelial Growth
Factor Receptor

Tumor endothelial
cells

Doxil® ElBayoumi and Torchilin

( 2009 )

ERBB-2 receptor Anti-ERBB2

(Herceptin)

Breast and ovarian
cancer cells

Anti-ERBB2-Hygromycin
conjugated phage
particles

Receptor mediated
endocytosis

Bar et al. ( 2008 )

SMA Aptamer Prostate tumor cells Pt(IV) prodrug-PLGA-

PEG nanoparticles

Receptor mediated
endocytosis

Dhar et al. ( 2008 )

(continued)