Biomedical Engineering Reference
In-Depth Information
products could be responsible for toxicity (Erdogu and Hasirci 1998 ). In parallel,
silica particles have long been used in the formulation of oral drugs, although recent
concerns have been raised about their capacity to induce sarcoidosis, that was pre-
viously observed for crystalline silica particle only (Sola et al. 2009 ).
Nevertheless, most recent studies related to silica particle cytotoxicity were trig-
gered by the possibility to use silica-based silica particles for systemic drug delivery.
A representative list of cell/particle systems that have been used for in vitro studies
have been gathered on Table 1 .
Table 1 Examples of in vitro evaluation of silica nanoparticles
Cell
Particle structure
Particle size (nm)
Refs
Embryonic kidney
cells
Plain
20, 50
Wang et al. ( 2009 )
Hepatic cells
Plain
20, 50, 85
Ye et al. ( 2010 )
Keratinocytes
Plain
7, 10-20
Gong et al. ( 2010 )
Endothelial cells
Plain
20
Liu and Sun ( 2010 )
Lung epithelial
Plain
10, 80
Akhtar et al. ( 2010 )
Primary microglia
Plain
150-200
Choi et al. ( 2010 )
Jurkat cells
Plain and
mesoporous-
amine-coated
300
Tao et al. ( 2009 )
Human neuroblastoma
Mesoporous-amine-
and thiol-coated
250
Di Pasqua et al. ( 2008 )
Monocyte-derived
dendritic cells
Mesoporous
270
Vallhov et al. ( 2007 )
HeLa
Mesoporous
30-280
Lu et al. ( 2009 )
Mesoporous-ODN
intercalator-coated
220, 300
Vivero-Escoto et al.
( 2010a )
Human red blood cells
(HRB)
Plain and
mesoporous-PEG-
coated
25, 40, 95,
155, 225
Lin and Haynes ( 2010 )
HRB/leukemia-derived
macrophages
Mesoporous-PEG-
coated
150
He et al. ( 2010 )
Human mesothelial/
Mouse peritoneal
macrophage/Mouse
myoblast (muscle)
cells
Mesoporous
100-150,
700-800
Hudson et al. ( 2008 )
Human fibroblasts (HF)
Plain
50, 80
Zhang et al. ( 2010 )
HF/tumor cells
Hybrid chitosan/silica
150-200
Chang et al. ( 2007 )
3 T3-L1 fibroblasts
Plain
20, 30, 240
Barnes et al. ( 2008 )
Plain
10, 30, 80, 400
Park et al. ( 2010 )
Hybrid gelatin/silica
400-500
Allouche et al. ( 2006 )
HF/Chinese Hamster
Ovarian
Mesoporous
100, 500
Trewyn et al. ( 2008 )
Lung cancer cells
Crystalline
15, 46
Lin et al. ( 2006 )
Mouse embryo
fibroblasts
Crystalline
20
Yang et al. ( 2009 )
 
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