Silica-Based Nanoparticles for Intracellular Drug Delivery - Intracellular Delivery: Fundamentals and Applications - page 333

Silica-Based Nanoparticles for Intracellular
Drug Delivery

Sandrine Quignard, Sylvie Masse, and Thibaud Coradin

Abstract Silica-based nanoparticles have recently raised a great deal of attention
as possible drug carriers. Such an interest is driven by the possibility to control
their size, the chemical composition and the porous structure as well as to easily
modify their surface with a wide range of biologically-relevant functionalities,
favoring colloidal stability, long-time blood circulation and even specific targeting.
Drug loading can be performed during particle formation but, at this time, the most
popular method relies on the impregnation of pre-formed mesoporous colloids.
Strategies to control drug delivery via bio-responsive pore capping are also devel-
oped. However, despite an increasing number of in vitro and in vivo studies related
to the interaction of silica particles with cells and animals, their biocompatibility is
still an issue, especially if applications in intracellular drug delivery are foreseen.

Keywords Silica • Organosilanes • Mesoporous particles • Hybrid materials

Abbreviations

FITC fluorescein isothiocyanate

HSN hollow silica nanoparticles

MSN mesoporous silica nanoparticles

PEG polyethylene glycol

PEI polyethylene imine

PLGA poly(lactic-co-glycolic acid)

PLLA poly-L-lactic acid

PVP polyvinylpyrrolidone

S. Quignard, S. Masse, and T. Coradin ( * )
CNRS, Laboratoire de Chimie de la Matière Condensée de Paris,
Collège de France, UPMC Univ Paris 06, 11 Place Marcelin Berthelot,
F-75005 Paris, France
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